(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Base Information

Chemical Name:(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt
CAS No.:135426-80-1
Molecular Formula:C₂₈H₃₁FNO₅P*2Na
Molecular Weight:557.51
Hs Code.:

Synonyms:(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Suppliers and Price of (S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

There total 13 articles about (S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135426-80-1
(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Guidance literature:: Multi-step reaction with 12 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

9: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg Cto -78 deg C, 30 min

10: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

11: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

12: aq. NaOH / dioxane / Heating

With piperidine; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; acetic acid; dimethyl sulfoxide; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-90-4
5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxaldehyde

: 135426-80-1
(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

2: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

4: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg Cto -78 deg C, 30 min

5: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

6: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

7: aq. NaOH / dioxane / Heating

With sodium hydroxide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; acetic acid; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jm00113a019

Reference yield:

: 135426-24-3
5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol

: 135426-80-1
(S)-4-[[2-[5-Ethyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

2: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

3: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

4: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

5: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg Cto -78 deg C, 30 min

6: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

7: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

8: aq. NaOH / dioxane / Heating

With sodium hydroxide; n-butyllithium; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; acetic acid; dimethyl sulfoxide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1021/jm00113a019