(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

Base Information

Chemical Name:(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole
CAS No.:1350980-06-1
Molecular Formula:C₂₆H₂₂N₂O₅S
Molecular Weight:474.537
Hs Code.:

Synonyms:(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

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Chemical Property of (S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

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Technology Process of (S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

There total 10 articles about (S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1350980-10-7
(S)-1-(1-(benzyloxy)-3-(p-nitrophenylsulfonamido)propan-2-yl)naphthalen-2-yl trifluoromethanesulfonate

: 1350980-06-1
(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

Guidance literature:: With copper(l) iodide; cesium acetate; In dimethyl sulfoxide; at 120 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.10.105

Reference yield:

: 100-44-7
benzyl chloride

: 1350980-06-1
(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide

1.2: 10 - 60 °C

2.1: ammonium cerium (IV) nitrate; sodium nitrite / acetonitrile / 0 - 20 °C

3.1: C₂₈H₂₈F₆N₄S / toluene / 96 h / -50 °C / Molecular sieve

4.1: ammonium chloride; zinc / ethanol; water / 72 h / 20 °C

5.1: pyridine / 4 h / 0 °C

6.1: triethylamine / dichloromethane / 10 °C

7.1: copper(l) iodide; cesium acetate / dimethyl sulfoxide / 12 h / 120 °C / Inert atmosphere

With pyridine; copper(l) iodide; ammonium cerium (IV) nitrate; C₂₈H₂₈F₆N₄S; cesium acetate; ammonium chloride; triethylamine; potassium hydroxide; zinc; sodium nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; 3.1: Friedel Crafts alkylation;
DOI:10.1016/j.tetlet.2011.10.105

Reference yield:

: 14593-43-2
benzyl allyl ether

: 1350980-06-1
(S)-1-((benzyloxy)methyl)-3-((p-nitrophenyl)sulfonyl)-2,3-dihydro-1H-benzo[e]indole

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium cerium (IV) nitrate; sodium nitrite / acetonitrile / 0 - 20 °C

2: C₂₈H₂₈F₆N₄S / toluene / 96 h / -50 °C / Molecular sieve

3: ammonium chloride; zinc / ethanol; water / 72 h / 20 °C

4: pyridine / 4 h / 0 °C

5: triethylamine / dichloromethane / 10 °C

6: copper(l) iodide; cesium acetate / dimethyl sulfoxide / 12 h / 120 °C / Inert atmosphere

With pyridine; copper(l) iodide; ammonium cerium (IV) nitrate; C₂₈H₂₈F₆N₄S; cesium acetate; ammonium chloride; triethylamine; zinc; sodium nitrite; In ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; 2: Friedel Crafts alkylation;
DOI:10.1016/j.tetlet.2011.10.105