(R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester

Base Information

• Chemical Name: (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester
• CAS No.: 618097-75-9
• Molecular Formula: C₂₅H₂₃NO₂
• Molecular Weight: 369.463
• Mol file: 618097-75-9.mol

Synonyms:(R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester

Chemical Property of (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester

There total 8 articles about (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-triphenylmethyl-(R)-serine(O-methanesulfonyl) allyl ester (503565-00-2) → (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester (618097-75-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/jo0346398

Reference yield: 74.0%

(R)-tert-butyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-mercaptopropanoate (172322-96-2) + N-triphenylmethyl-β-iodo-(S)-alanine allyl ester (503565-01-3) → (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester (618097-75-9) + (2S,6R)-N2-triphenylmethyl-N6-(9H-fluorenylmethoxycarbonyl)-lanthionine O1-allyl-O7-tert-butyl ester (503565-02-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 4h;

DOI:10.1016/S0040-4020(02)01091-8

Reference yield: 72.0%

(R)-allyl 3-hydroxy-2-(tritylamino)propanoate (503564-99-6) → (R)-1-triphenylmethylaziridine-2-carboxylic acid allyl ester (618097-75-9) + N-triphenylmethyl-β-iodo-(S)-alanine allyl ester (503565-01-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; methyl iodide; In dichloromethane; at -2 ℃; for 3h;

DOI:10.1021/jo048222t

upstream raw materials:

(R)-tert-butyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-mercaptopropanoate

N-triphenylmethyl-β-iodo-(S)-alanine allyl ester

N-triphenylmethyl-(R)-serine(O-methanesulfonyl) allyl ester

(R)-allyl 3-hydroxy-2-(tritylamino)propanoate

Downstream raw materials:

1-(p-nitrobenzyloxycarbonyl)aziridine-2R-carboxylic acid allyl ester

(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-((S)-3-(allyloxy)-2-(2,4-dinitrobenzenesulfonamido)-3-oxopropylthio)propanoic acid

(R)-allyl 1-(2,4-dinitrobenzenesulfonyl)aziridine-2-carboxylate