spiropentaneacetic acid

Base Information

• Chemical Name: spiropentaneacetic acid
• CAS No.: 14364-43-3
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.155
• Mol file: 14364-43-3.mol

Synonyms:Spiro[2.2]pentaneaceticacid (9CI); Spiropentaneacetic acid (8CI); Spiropentylacetic acid

Chemical Property of spiropentaneacetic acid

Chemical Property:

• Vapor Pressure: 0.0159mmHg at 25°C
• Boiling Point: 236.7°Cat760mmHg
• PKA: 4.70±0.10(Predicted)
• Flash Point: 123.4°C
• PSA: 37.30000
• Density: 1.22g/cm³
• LogP: 1.26120

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of spiropentaneacetic acid

There total 12 articles about spiropentaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2-hydroxyethyl)spiropentane (118757-50-9) → spiropentaneacetic acid (14364-43-3)

Guidance literature:

With sodium hypochlorite; sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; Aliquat 336; In dichloromethane; for 0.166667h; Ambient temperature; pH 9;

DOI:10.1021/jo00065a026

Reference yield:

2-(methylenecyclopropyl)ethan-1-ol (120477-28-3) → spiropentaneacetic acid (14364-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / Jones reagent / acetone / 1 h

2: 2.) Pd(OAc)2 / 1.) eter, 10 min, 2.) eter, 2 h

3: aq. NaOH / ethanol / 0.17 h / Heating

With palladium diacetate; sodium hydroxide; jones reagent; In ethanol; acetone;

DOI:10.1021/ja9737634

Reference yield:

methyl spiropentylacetate (114720-65-9) → spiropentaneacetic acid (14364-43-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.166667h; Heating;

DOI:10.1021/ja9737634

upstream raw materials:

(2-hydroxyethyl)spiropentane

methyl spiropentylacetate

(methylenecyclopropyl)acetic acid

2-(methylenecyclopropyl)ethan-1-ol

Refernces

• 1、 Li, Ding,Zhou, Hui-Qiang,Dakoji, Srikanth,Shin, Injae,Oh, Eugene,Liu, Hung-Wen. "Spiropentylacetyl-CoA, a mechanism-based inactivator of acyl-CoA dehydrogenases". . p. 2008 - 2017. Retrieved 2007/10/03.