(3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Base Information

• Chemical Name: (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
• CAS No.: 865451-74-7
• Molecular Formula: C₂₄H₂₈FN₃O₆
• Molecular Weight: 473.501
• Mol file: 865451-74-7.mol

Synonyms:(3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Chemical Property of (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

There total 9 articles about (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

1-(4-amino-3-fluoro-phenyl)-pyridin-2-one (536747-52-1) → (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (865451-74-7)

Guidance literature:

(R,R)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 0.5h;

1-(4-amino-3-fluoro-phenyl)-pyridin-2-one; In acetonitrile; at 25 ℃; for 96h;

Reference yield: 58.0%

(R,R)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester (595556-31-3,1212409-03-4,1309251-07-7,252919-44-1) + 1-(4-amino-3-fluoro-phenyl)-pyridin-2-one (536747-52-1) → (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (865451-74-7)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 ℃; for 96h;

DOI:10.1016/j.bmcl.2010.06.126

Reference yield:

C18H29NO8 + 1-(4-amino-3-fluoro-phenyl)-pyridin-2-one (536747-52-1) → (3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)phenylcarbamoyl]pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (865451-74-7)

Guidance literature:

In tetrahydrofuran; Heating / reflux;

upstream raw materials:

1-(4-amino-3-fluoro-phenyl)-pyridin-2-one

(R,R)-pyrrolidine-1,3,4-tricarboxylic acid 1-tert-butyl ester 3-ethyl ester

diethyl trans-N-benzyl-pyrrolidine-3,4-dicarboxylate

diethyl Fumarate

Downstream raw materials:

(3R,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-pyrrolidine-3-carboxylic acid ethyl ester hydrochloride

C₁₉H₂₀FN₃O₄