(2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate
• CAS No.: 1263315-52-1
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.48

Synonyms:(2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate

Chemical Property of (2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate

There total 1 articles about (2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + (4S,5S)-4-<<(phenylmethoxy)carbonyl>amino>-5-(2'-methylpropyl)-2-oxopyrrolidine (109292-04-8) → (2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate (1263315-52-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1039/c0ob00370k

Reference yield: 95.0%

(2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate (1263315-52-1) → methyl (3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoate (104021-83-2)

Guidance literature:

With sodium methylate; In methanol; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c0ob00370k

Reference yield: 86.0%

(2S,3S)-tert-butyl 3-(benzyloxycarbonylamino)-2-isobutyl-5-oxopyrrolidine-1-carboxylate (1263315-52-1) → (3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid (100512-24-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

DOI:10.1039/c0ob00370k

upstream raw materials:

di-tert-butyl dicarbonate

(4S,5S)-4-<<(phenylmethoxy)carbonyl>amino>-5-(2'-methylpropyl)-2-oxopyrrolidine

Downstream raw materials:

(3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoic acid

methyl (3S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-6-methyl-3-<<(phenylmethoxy)carbonyl>amino>heptanoate

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