2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide

Base Information

• Chemical Name: 2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide
• CAS No.: 1396684-71-1
• Molecular Formula: C₂₄H₃₂FN₃O₂S₂
• Molecular Weight: 477.667
• Mol file: 1396684-71-1.mol

Synonyms:2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide

Chemical Property of 2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide

There total 1 articles about 2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-fluorophenyl isothiocyanate (404-72-8) + S-(3,5-di-tert-butyl-4-hydroxybenzyl)thioglycolic acid hydrazide (123372-63-4) → 2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide (1396684-71-1)

Guidance literature:

In toluene; at 20 ℃;

DOI:10.3390/molecules17077645

Reference yield: 70.0%

2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide (1396684-71-1) → 3-((3,5-di-tert-butyl-4-hydroxybenzylthio)methyl)-4-(3-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione (1396684-75-5)

Guidance literature:

2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide; With potassium carbonate; In water; for 18h;

pH=5 - 6; Acidic conditions;

DOI:10.3390/molecules17077645

Reference yield: 60.0%

2-(2-(3,5-di-tert-butyl-4-hydroxybenzylthio)acetyl)-N-(3-luorophenyl)hydrazinecarbothioamide (1396684-71-1) → 2,6-di-tert-butyl-4-(((5-(3-fluorophenylamino)-1,3,4-thiadiazol-2-yl)methylthio)methyl)phenol (1396684-72-2)

Guidance literature:

With sulfuric acid; at 100 ℃; for 0.5h; Cooling;

DOI:10.3390/molecules17077645

upstream raw materials:

3-fluorophenyl isothiocyanate

S-(3,5-di-tert-butyl-4-hydroxybenzyl)thioglycolic acid hydrazide

Downstream raw materials:

2,6-di-tert-butyl-4-(((5-(3-fluorophenylamino)-1,3,4-thiadiazol-2-yl)methylthio)methyl)phenol

3-((3,5-di-tert-butyl-4-hydroxybenzylthio)methyl)-4-(3-fluorophenyl)-1H-1,2,4-triazole-5(4H)-thione