(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

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Chemical Name:(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene
CAS No.:171296-56-3
Molecular Formula:C₂₂H₂₂O₇
Molecular Weight:398.412
Hs Code.:

Synonyms:(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

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Chemical Property of (-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

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Technology Process of (-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

There total 14 articles about (-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 199996-64-0
[(5R,6S)-7-[1,3]Dithiolan-2-yl-5-(3,4,5-trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxol-6-yl]-methanol

: 171296-56-3
(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

Guidance literature:: With boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; water; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10042-4

Reference yield:

: (1S,2R)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2,3-di(hydroxymethyl)naphthalene

: 171296-56-3
(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 5.5h; enantioselective reaction; Inert atmosphere;
DOI:10.1246/cl.141061

Reference yield:

: 199996-63-9
(5R,6S)-7-[1,3]Dithiolan-2-yl-5-(3,4,5-trimethoxy-phenyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester

: 171296-56-3
(-)-(1R,2S)-1,2-dihydro-1-(3,4,5-trimethoxyphenyl)-2-(hydroxymethyl)-3-formylnaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / diethyl ether / 20 °C

2: 94 percent / HgO; BF₃*Et₂O / tetrahydrofuran; H₂O / 3 h / 20 °C

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; diethyl ether; water; 1: Reduction / 2: Ring cleavage;
DOI:10.1016/S0223-5234(00)00176-8