tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

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Chemical Name:tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane
CAS No.:851626-27-2
Molecular Formula:C₂₇H₃₈O₃Si
Molecular Weight:438.682
Hs Code.:

Synonyms:tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

There total 3 articles about tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 851626-25-0
(4S)-2-methyl-4-(tetrahydropyran-2'-yloxy)pent-2-en-1-ol

: 851626-27-2
tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.tetasy.2004.12.029

Reference yield:

: 76438-34-1
(S)-2-(tetrahydropyranyloxy)propanal

: 851626-27-2
tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C

1.2: 82 percent / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: diisobutylaluminum hydride / CH₂Cl₂ / 1.17 h / -78 °C

3.1: 72 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1.1: Wittig-Horner-Emmons reaction;
DOI:10.1016/j.tetasy.2004.12.029

Reference yield:

: 851682-47-8
(Z)-(S)-2-Methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enoic acid ethyl ester

: 851626-27-2
tert-Butyl-[(Z)-(S)-2-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-enyloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminum hydride / CH₂Cl₂ / 1.17 h / -78 °C

2: 72 percent / imidazole / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1016/j.tetasy.2004.12.029