3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

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Chemical Name:3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid
CAS No.:1291090-49-7
Molecular Formula:C₃₁H₃₈N₂O₈
Molecular Weight:566.651
Hs Code.:

Synonyms:3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

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Chemical Property of 3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

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Technology Process of 3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

There total 8 articles about 3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1291090-50-0
tert-butyl 3-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)propanoate

: 1291090-54-4
tert-butyl 8-(4-(dimethylamino)phenyl)-1-(2-hydroxyethyl)-2-methyl-7-oxopyrano[3,2-e]indole-3(7H)-carboxylate

: 1291090-49-7
3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

Guidance literature:: tert-butyl 8-(4-(dimethylamino)phenyl)-1-(2-hydroxyethyl)-2-methyl-7-oxopyrano[3,2-e]indole-3(7H)-carboxylate; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

tert-butyl 3-(2-(2-(2-iodoethoxy)ethoxy)ethoxy)propanoate; In N,N-dimethyl-formamide; for 4h;

With trifluoroacetic acid; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 1291090-51-1
2-(8-bromo-2-methyl-7-oxo-3,7-dihydropyrano[3,2-e]indol-1-yl)ethyl acetate

: 1291090-49-7
3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 0.08 h / 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / ethanol; toluene / 6 h / 90 °C / Inert atmosphere

3.1: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 4 h

4.3: 0 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; water; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.tet.2011.01.075

Reference yield:

: 1291090-52-2
tert-butyl 1-(2-acetoxyethyl)-8-bromo-2-methyl-7-oxopyrano[3,2-e]indole-3(7H)-carboxylate

: 1291090-49-7
3-{2-[2-(2-{2-[8-(4-dimethylamino-phenyl)-2-methyl-7-oxo-3,7-dihydro-pyrano[3,2-e]indol-1-yl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate / ethanol; toluene / 6 h / 90 °C / Inert atmosphere

2.1: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 4 h

3.3: 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; water; potassium carbonate; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1016/j.tet.2011.01.075