3-bromo-4,5-dimethoxybenzoyl chloride

Base Information

• Chemical Name: 3-bromo-4,5-dimethoxybenzoyl chloride
• CAS No.: 70574-46-8
• Molecular Formula: C₉H₈BrClO₃
• Molecular Weight: 279.518
• Mol file: 70574-46-8.mol

Synonyms:3-bromo-4,5-dimethoxybenzoyl chloride

Chemical Property of 3-bromo-4,5-dimethoxybenzoyl chloride

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-4,5-dimethoxybenzoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4,5-dimethoxybenzoyl chloride

There total 4 articles about 3-bromo-4,5-dimethoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-4,5-dimethoxybenzoic acid (20731-48-0) → 3-bromo-4,5-dimethoxybenzoyl chloride (70574-46-8)

Guidance literature:

With thionyl chloride;

Reference yield:

5-bromoveratralaldehyde (6948-30-7) → 3-bromo-4,5-dimethoxybenzoyl chloride (70574-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: urea hydrogen peroxide adduct / methanol / 1.5 h / Reflux

2: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 20 °C

With thionyl chloride; urea hydrogen peroxide adduct; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acscombsci.8b00113

Reference yield:

Veratric acid (93-07-2) → 3-bromo-4,5-dimethoxybenzoyl chloride (70574-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / tetrachloromethane / 24 h / 50 °C

2: thionyl chloride; N,N-dimethyl-formamide / 2 h / 80 - 90 °C

With thionyl chloride; bromine; N,N-dimethyl-formamide; In tetrachloromethane;

DOI:10.2174/1573406411309020013

upstream raw materials:

3-bromo-4,5-dimethoxybenzoic acid

Veratric acid

5-bromoveratralaldehyde

Downstream raw materials:

1-(3-bromo-4,5-dimethoxyphenyl)ethanone