2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole

Base Information

• Chemical Name: 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole
• CAS No.: 1190235-58-5
• Molecular Formula: C₁₁H₈F₃NOS
• Molecular Weight: 259.252
• Mol file: 1190235-58-5.mol

Synonyms:2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole

Chemical Property of 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole

There total 3 articles about 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylate (132089-39-5) → 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole (1190235-58-5)

Guidance literature:

ethyl 2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylate; With lithium borohydride; In tetrahydrofuran; at 0 - 80 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield: 36.0%

oxetan-3-one (6704-31-0) + 3-(trifluoromethyl)benzothioamide (53515-17-6) → 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole (1190235-58-5)

Guidance literature:

With methanesulfonic acid; carbonic acid dimethyl ester; at 120 ℃; for 3h; Microwave irradiation;

DOI:10.1002/chem.201301011

Reference yield:

3-trifluoromethylbenzamide (1801-10-1) → 2-(3-trifluoromethylphenyl)-4-hydroxymethylthiazole (1190235-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂S₅/alumina / tetrahydrofuran / 0.33 h / 60 °C / Microwave irradiation

2: methanesulfonic acid; carbonic acid dimethyl ester / 3 h / 120 °C / Microwave irradiation

With methanesulfonic acid; P₂S₅/alumina; carbonic acid dimethyl ester; In tetrahydrofuran;

DOI:10.1002/chem.201301011

upstream raw materials:

ethyl 2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylate

3-trifluoromethylbenzamide

oxetan-3-one

3-(trifluoromethyl)benzothioamide

Downstream raw materials:

{2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methyl acetate

4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole

Refernces

• 1、 -. "HETEROCYCLIC DERIVATIVE AND USE THEREOF". Page/Page column 162. . Retrieved 2011/01/11.