9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

Base Information

Chemical Name:9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine
CAS No.:911432-15-0
Molecular Formula:C₄₃H₅₅N₅O₇Si
Molecular Weight:782.024
Hs Code.:

9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

Synonyms:9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

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Chemical Property of 9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

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Technology Process of 9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

There total 2 articles about 9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 911432-10-5
2-(2-{9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-imino-6,9-dihydro-purin-1-yl}-ethoxy)-ethanol

: 14470-28-1
mono-4-methoxytrityl chloride

: 911432-15-0
9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

Guidance literature:: With pyridine; at 20 ℃; for 8h;
DOI:10.1021/jm060320e

Reference yield:

: 368870-20-6
5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile

: 911432-15-0
9-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1-(2-{2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-1,9-dihydro-purin-6-ylideneamine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / methanol / 4 h / 20 °C

2: 90 percent / pyridine / 8 h / 20 °C

With pyridine; potassium carbonate; In methanol;
DOI:10.1021/jm060320e