3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole

Base Information

• Chemical Name: 3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole
• CAS No.: 28687-71-0
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.279
• Mol file: 28687-71-0.mol

Synonyms:3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole

Chemical Property of 3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole

There total 19 articles about 3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-nitro-1-phenylmethane (622-42-4) + norbornene (498-66-8) → 3-phenyl-3a,6,7,7a-tetrahydro-4,7-methano-benzo2-isoxazoline (28687-71-0,52746-68-6)

Guidance literature:

1-nitro-1-phenylmethane; With dmap; di-tert-butyl dicarbonate; In toluene; at 25 ℃;

norbornene; In toluene; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/ol026846k

Reference yield: 98.0%

norborn-2-ene (498-66-8) + 1-nitro-1-phenylmethane (622-42-4) → 3-phenyl-3a,4,5,6,7,7a-hexahydro-4,7-methano-1,2-benzisoxazole (28687-71-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In chloroform; at 60 ℃; for 72h;

DOI:10.1002/ejoc.200700276

Reference yield: 95.0%

norbornene (498-66-8) + Benzaldoxime (932-90-1) → 3-phenyl-3a,6,7,7a-tetrahydro-4,7-methano-benzo2-isoxazoline (28687-71-0,52746-68-6)

Guidance literature:

With [bis(acetoxy)iodo]benzene; trifluoroacetic acid; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol900194v

upstream raw materials:

norborn-2-ene

1-nitro-1-phenylmethane

3-Phenyl-7aH-1-oxa-2,3a,4-triaza-indene

benzonitrile oxide

Downstream raw materials:

5,8-methano-r-4-phenyl-2-phenylimino-c-4a,c-5,6,7,c-8,c-8a-hexahydro-4H-1,3-benzoxazine

5,8-methano-r-4-phenyl-2-p-tolyl-c-4a,c-5,6,7,c-8,c-8a-hexahydro-4H-1,3-benzoxazine

(1S,2R,7R,8R,9R)-4-Methyl-7-phenyl-3-oxa-6-aza-tricyclo[7.2.1.0^2,8]dodecan-5-one

6,9-methano-r-5-phenyl-c-5a,c-6,7,8,c-9,c-9a-hexahydro-1,4-benzoxazepin-3(4H)-one