tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

Base Information

Chemical Name:tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate
CAS No.:1401067-07-9
Molecular Formula:C₂₁H₂₆F₃NO₅
Molecular Weight:429.436
Hs Code.:

Synonyms:tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

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Chemical Property of tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

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Technology Process of tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

There total 5 articles about tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1401065-46-0
(4S)-4-benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one

: 1401067-07-9
tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

Guidance literature:: (4S)-4-benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 6h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00001

Reference yield:

: 1186202-35-6
5,5,5-trifluoro-n-valeryl chloride

: 1401067-07-9
tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

1.2: 0.58 h / -78 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

: 407-62-5
5,5,5-trifluoropentanoic acid

: 1401067-07-9
tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

2.2: 0.58 h / -78 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;