Technology Process of tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate
There total 5 articles about tert-butyl (3R)-3-(((4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl)-6,6,6-trifluorohexanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4S)-4-benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
Inert atmosphere;
bromoacetic acid tert-butyl ester;
In
tetrahydrofuran;
at -78 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/acsmedchemlett.5b00001
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
1.2: 0.58 h / -78 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2.2: 6 h / -78 °C / Inert atmosphere
With
n-butyllithium; sodium hexamethyldisilazane;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h
2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
2.2: 0.58 h / -78 °C
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
3.2: 6 h / -78 °C / Inert atmosphere
With
n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane;
