18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester

Base Information

• Chemical Name: 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester
• CAS No.: 123291-90-7
• Molecular Formula: C₃₇H₃₈O₈
• Molecular Weight: 610.704
• Mol file: 123291-90-7.mol

Synonyms:18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester

Chemical Property of 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester

There total 1 articles about 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

propane-1,3-diol ditosylate (5469-66-9) + diethyl 2',2'''-diethoxy-2,2''-dihydroxy-<1,1':3',1'':3'',1'''-quaterphenyl>-3,3'''-dicarboxylate (123291-89-4) → 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester (123291-90-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; 1a.) 75 deg C, 4 h, b.) 12 h;

DOI:10.1021/jo00284a018

Reference yield: 69.0%

18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester (123291-90-7) → 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-methanol, 19-ethoxy-10-<2-ethoxy-3-(hydroxymethyl)phenyl>-7,8-dihydro- (123291-91-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 18h;

DOI:10.1021/jo00284a018

Reference yield:

18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-carboxylic acid, 19-ethoxy-10-<2-ethoxy-3-(ethoxycarbonyl)phenyl>-7,8-dihydro-, ethyl ester (123291-90-7) → 18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin, 4-(bromomethyl)-10-<3-(bromomethyl)-2-ethoxyphenyl>-19-ethoxy-7,8-dihydro- (123291-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / LiAlH₄ / diethyl ether / 18 h

2: 68 percent / PBr₃ / benzene / 1 h / 25 °C

With lithium aluminium tetrahydride; phosphorus tribromide; In diethyl ether; benzene;

DOI:10.1021/jo00284a018

upstream raw materials:

propane-1,3-diol ditosylate

diethyl 2',2'''-diethoxy-2,2''-dihydroxy-<1,1':3',1'':3'',1'''-quaterphenyl>-3,3'''-dicarboxylate

Downstream raw materials:

18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin-4-methanol, 19-ethoxy-10-<2-ethoxy-3-(hydroxymethyl)phenyl>-7,8-dihydro-

18,14-metheno-6H,14H-dibenzo<1,5>dioxacyclotetradecin, 4-(bromomethyl)-10-<3-(bromomethyl)-2-ethoxyphenyl>-19-ethoxy-7,8-dihydro-