1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

Base Information

Chemical Name:1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole
CAS No.:859832-48-7
Molecular Formula:C₂₁H₂₃BrN₂O₃S
Molecular Weight:463.395
Hs Code.:

Synonyms:1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

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Chemical Property of 1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

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Technology Process of 1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

There total 6 articles about 1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1325212-47-2
C₁₅H₂₀N₂O

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 859832-48-7
1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

Guidance literature:: C₁₅H₂₀N₂O; With sodium hydride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 0.5h; Inert atmosphere;

o-bromobenzenesulfonyl chloride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 1325212-39-2
C₁₅H₁₆N₂O₃

: 859832-48-7
1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

2.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 930-88-1
N-methylmaleimide

: 859832-48-7
1-(2-bromobenzenesulfonyl)-3-(1-methylpyrrolidin-3-yl)-5-ethoxy-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; methyl iodide / tetrahydrofuran / 1 h / 25 - 30 °C / Inert atmosphere

1.2: 3 h / 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

3.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; magnesium; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106