5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole

Base Information

• Chemical Name: 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole
• CAS No.: 10173-74-7
• Molecular Formula: C15H13 N3 O2
• Molecular Weight: 267.2826
• Mol file: 10173-74-7.mol

Synonyms:Benzimidazole,5,6-dimethyl-2-(o-nitrophenyl)- (7CI,8CI); NSC 128742

Chemical Property of 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole

Chemical Property:

• Vapor Pressure: 2.46E-10mmHg at 25°C
• Boiling Point: 505.3°C at 760 mmHg
• Flash Point: 259.4°C
• Density: 1.305g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole

There total 4 articles about 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,5-dimethyl-1,2-phenylenediamine (3171-45-7) + 2-nitro-benzaldehyde (552-89-6) → 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole (10173-74-7)

Guidance literature:

With Oxone; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1080/00397910701489453

Reference yield:

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) + 2-nitro-benzaldehyde (552-89-6) → 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole (10173-74-7)

Guidance literature:

4,5-dimethyl-2-nitrobenzenamine; With 5%-palladium/activated carbon; ammonium formate; In toluene; at 120 ℃; for 1h;

2-nitro-benzaldehyde; In toluene; at 4 - 20 ℃; for 16h;

DOI:10.1002/ejoc.201201101

Reference yield:

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) → 5,6-dimethyl-2-(2-nitrophenyl)-1H-benzimidazole (10173-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / methanol / 2 h / 20 °C / 1551.49 Torr

2: 87 percent / oxone (R) / dimethylformamide / 2 h / 20 °C

With Oxone; hydrogen; In methanol; N,N-dimethyl-formamide;

DOI:10.1080/00397910701489453

upstream raw materials:

4,5-dimethyl-1,2-phenylenediamine

2-nitro-benzaldehyde

4,5-dimethyl-2-nitrobenzenamine

Refernces

• 1、 Saha, Biswajit,Sharma, Sunil,Kundu, Bijoy. "Efficient method for the synthesis of benzimidazoquinazoline derivatives with three-point diversity". . p. 3455 - 3470. Retrieved 2008/02/13.