Technology Process of (R)-2-<4-phenoxy>propanoic acid
There total 4 articles about (R)-2-<4-phenoxy>propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 18h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 67 percent / DCC / 4-(N-pyrrolidino)pyridine / CH2Cl2 / 18 h / Ambient temperature
2: 79 percent / H2 / 5percent Pd/C / ethyl acetate / 18 h / Ambient temperature
With
hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal; 4-pyrrolidin-1-ylpyridine;
In
dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / 20percent aq. K2CO3 / methanol; H2O; dimethylformamide / 1.) pH 7.00, 2.) room temp., 48 h
2: 67 percent / DCC / 4-(N-pyrrolidino)pyridine / CH2Cl2 / 18 h / Ambient temperature
3: 79 percent / H2 / 5percent Pd/C / ethyl acetate / 18 h / Ambient temperature
With
hydrogen; potassium carbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal; 4-pyrrolidin-1-ylpyridine;
In
methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
