ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate
CAS No.:98476-13-2
Molecular Formula:C14H13N3O2
Molecular Weight:255.2719
Hs Code.:

Synonyms:5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester;Ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate;ethyl 5-cyano-1-(3-methylphenyl)-4-pyrazolecarboxylate;1H-Pyrazole-4-carboxylic acid,5-cyano-1-(3-methylphenyl)-,ethyl ester;5-cyano-1-(m-tolyl)-1H-pyrazole-4-carboxylic acid ethyl ester;

Suppliers and Price of ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate

Chemical Property:

Vapor Pressure:6.8E-08mmHg at 25°C
Boiling Point:438.6°C at 760 mmHg
Flash Point:219.1°C
PSA：67.91000
Density:1.18g/cm³
LogP:2.22908

Purity/Quality:

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Technology Process of ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate

There total 4 articles about ethyl 5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 143-33-9,25596-52-5
sodium cyanide

: 117378-04-8
1-(3-methylphenyl)-5-(methylsulfonyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 98476-13-2
5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 0.583333h;

Reference yield:

: 117378-01-5
1-(3-methylphenyl)-5-(methylthio)-1H-pyrazole-4-carboxylic acid ethyl ester

: 98476-13-2
5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 30percent H₂O₂ / acetic acid / 1 h / heating on a steam bath

2: 96 percent / dimethylformamide / 0.58 h / 80 °C

With dihydrogen peroxide; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 15001-10-2
ethyl 5-amino-1-(m-tolyl)-1H-pyrazole-4-carboxylate

: 98476-13-2
5-cyano-1-(3-methylphenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / t-butyl nitrite / CHCl₃ / 1.) 50 deg C; 2.) reflux, 15 min

2: 30percent H₂O₂ / acetic acid / 1 h / heating on a steam bath

3: 96 percent / dimethylformamide / 0.58 h / 80 °C

With tert.-butylnitrite; dihydrogen peroxide; In chloroform; acetic acid; N,N-dimethyl-formamide;