2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride

Base Information

• Chemical Name: 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride
• CAS No.: 1108746-55-9
• Molecular Formula: C₁₃H₁₈N₂O₃*ClH
• Molecular Weight: 286.758
• Mol file: 1108746-55-9.mol

Synonyms:2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride

Chemical Property of 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride

There total 3 articles about 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methyl 2-methoxy-4-(4-methylpiperazin-1-yl)benzoate (1108746-54-8) → 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride (1108746-55-9)

Guidance literature:

methyl 2-methoxy-4-(4-methylpiperazin-1-yl)benzoate; With water; sodium hydroxide; In ethanol; at 70 ℃;

With hydrogenchloride; In water; at 0 ℃;

DOI:10.1021/acsmedchemlett.6b00066

Reference yield:

1-methyl-piperazine (109-01-3) → 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride (1108746-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 120 °C

2.1: sodium hydroxide; water / ethanol / 70 °C

2.2: 0 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/acsmedchemlett.6b00066

Reference yield:

methyl 4-fluoro-2-methoxybenzoate (204707-42-6) → 2-methoxy-4-(4-methylpiperazin-1-yl)benzoic acid hydrochloride (1108746-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 120 °C

2.1: sodium hydroxide; water / ethanol / 70 °C

2.2: 0 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/acsmedchemlett.6b00066

upstream raw materials:

methyl 2-methoxy-4-(4-methylpiperazin-1-yl)benzoate

1-methyl-piperazine

methyl 4-fluoro-2-methoxybenzoate