methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

Base Information

Chemical Name:methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate
CAS No.:1610460-65-5
Molecular Formula:C₂₆H₂₈ClNO₆S
Molecular Weight:518.03
Hs Code.:

Synonyms:methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

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Chemical Property of methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

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Technology Process of methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

There total 11 articles about methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85838-94-4
N-Boc-1,2,3,6-tetrahydropyridine

: 1610460-64-4
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

: 1610460-65-5
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

2.1: sodium hydroxide / water; acetonitrile / 24 h / 95 °C

3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - -65 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -5 - 0 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

6.1: potassium hydrogencarbonate / acetonitrile / 72 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; potassium hydrogencarbonate; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile; mineral oil; 3.1: |Swern Oxidation / 4.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2014.04.037

Reference yield:

: 223123-65-7
methyl (R)-2(4-chlorobenzenesulfonyloxyl)-2-(2-chlorophenyl)acetate

: 1610460-63-3
C₁₇H₂₁NO₄S

: 1610460-64-4
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

: 1610460-65-5
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

Guidance literature:: With potassium hydrogencarbonate; In acetonitrile; at 20 ℃; for 72h; Overall yield = 2 g; Inert atmosphere;
DOI:10.1016/j.tet.2014.04.037

Reference yield:

: tert-butyl 3-hydroxy-4-[(2-(3-methoxyphenyl)-1,3-dioxolan-2-yl)methylsulfanyl]piperidine-1-carboxylate

: 1610460-64-4
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

: 1610460-65-5
methyl (2S,3Z)-2-(2-chlorophenyl)-2-[3-(2-methoxy-2-oxoethylidene)-4-((2-(3-methoxyphenyl)-2-oxoethyl)sulfanyl)piperidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 - -65 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -5 - 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

4.1: potassium hydrogencarbonate / acetonitrile / 72 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; potassium hydrogencarbonate; dimethyl sulfoxide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; mineral oil; 1.1: |Swern Oxidation / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2014.04.037