5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide
CAS No.:1202920-36-2
Molecular Formula:C₂₆H₂₂ClN₃O₆
Molecular Weight:507.93
Hs Code.:

Synonyms:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Suppliers and Price of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

There total 2 articles about 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 747413-05-4
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

: 108-24-7
acetic anhydride

: 1202920-36-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Guidance literature:: With nitric acid; at 0 - 10 ℃;

Reference yield: 73.0%

: 747413-05-4
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethylamide

: 1202920-36-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

Guidance literature:: With nitric acid; acetic anhydride; at 0 - 10 ℃; for 70h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/jm201155e

Reference yield:

: 1202920-36-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

: 1202920-63-5
5-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-(3-morpholin-4-yl-propionylamino)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

2: triethylamine / dichloromethane / 5 h / Inert atmosphere

3: 1 h / Inert atmosphere; Reflux

With water; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane; 3: Michael addition;
DOI:10.1021/jm201155e