1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester
• CAS No.: 83785-70-0
• Molecular Formula: C₂₉H₃₀N₄O₃
• Molecular Weight: 482.582

Synonyms:1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Chemical Property of 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

There total 2 articles about 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloride (100-44-7) → 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester (83785-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / 60 - 70 °C

2: 93 percent / ethanol / 5 h / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.2399

Reference yield:

ethyl 7-chloro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (83785-66-4) → 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester (83785-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / anhydrous K₂CO₃ / dimethylformamide / 3 h / 60 - 70 °C

2: 93 percent / ethanol / 5 h / Heating

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.30.2399

Reference yield: 80.0%

1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester (83785-70-0) → 1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (83785-73-3)

Guidance literature:

With sodium hydroxide; at 100 ℃;

DOI:10.1248/cpb.30.2399

upstream raw materials:

benzyl chloride

ethyl 7-chloro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

Downstream raw materials:

1-Benzyl-7-(4-benzyl-piperazin-1-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

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