N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

Base Information

Chemical Name:N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide
CAS No.:1067193-12-7
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

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Chemical Property of N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

Chemical Property:

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Technology Process of N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

There total 21 articles about N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1067193-11-6
{3-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-3-methyl-butyl}-carbamic acid tert-butyl ester

: 1067193-12-7
N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: {3-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-3-methyl-butyl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 1067193-12-7
N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: aluminum (III) chloride / 17.33 h / 0 - 20 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

3: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C

4: sulfuric acid; potassium nitrate / dichloromethane / 16 h / 50 °C

5: borane-THF / tetrahydrofuran / 16.25 h / 80 °C

6: sodium hydroxide / 1,4-dioxane; water / 64 h / 20 °C

7: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 750.08 Torr

8: triethylamine / dichloromethane

9: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With aluminum (III) chloride; sodium hydroxide; borane-THF; oxalyl dichloride; sulfuric acid; hydrogen; ammonium hydroxide; potassium nitrate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 453562-77-1
2-methyl-2-(4-nitrophenyl)propionaldehyde

: 1067193-12-7
N-[4-(3-amino-1,1-dimethyl-propyl)-phenyl]-3,4-dimethoxy-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 20 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

2.2: pH 7

3.1: ammonium acetate; sodium cyanoborohydride / methanol / 20 °C

4.1: sodium hydroxide / 1,4-dioxane; water / 64 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 750.08 Torr

6.1: triethylamine / dichloromethane

7.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With sodium hydroxide; ammonium acetate; hydrogen; potassium hexamethylsilazane; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;