N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Base Information

Chemical Name:N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide
CAS No.:898269-98-2
Molecular Formula:C₄₁H₇₅NO₃Si₂
Molecular Weight:686.222
Hs Code.:

N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Synonyms:N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Suppliers and Price of N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

There total 6 articles about N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 898269-38-0
2,2,N-Trimethyl-N-[(R)-3-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-butyl]-propionamide

: 898269-98-2
N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Guidance literature:: [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.25h;

2,2,N-Trimethyl-N-[(R)-3-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-butyl]-propionamide; In tetrahydrofuran; hexanes; at -78 ℃; for 4h;

Reference yield: 31.0%

: 898269-38-0
2,2,N-Trimethyl-N-[(R)-3-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-butyl]-propionamide

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 898269-98-2
N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Guidance literature:: [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

2,2,N-Trimethyl-N-[(R)-3-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-butyl]-propionamide; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1016/j.bmc.2006.05.050

Reference yield:

: 6830-83-7
N-methyl-pivalamide

: 898269-98-2
N-((R)-3-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-butyl)-2,2,N-trimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 30 percent / sodium hydride / tetrahydrofuran / 20 h / Heating

2.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

3.1: 9.0 mg / pyridinium dichromate / CH₂Cl₂ / 12 h / 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

4.2: 31 percent / tetrahydrofuran; hexane / -78 °C

With dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2006.05.050