6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil

Base Information

Chemical Name:6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil
CAS No.:175739-42-1
Molecular Formula:C22H24N2O3
Molecular Weight:364.437560
Hs Code.:
UNII:2HRU1H9M1I
DSSTox Substance ID:DTXSID60170016
Nikkaji Number:J713.893H
Wikidata:Q27097826
Metabolomics Workbench ID:56639
ChEMBL ID:CHEMBL436546

Synonyms:TNK-651

Suppliers and Price of 6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 12 raw suppliers

Chemical Property of 6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil

Chemical Property:

Refractive Index:1.582
Density:1.172 g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:364.17869263
Heavy Atom Count:27
Complexity:558

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=C(N(C(=O)NC1=O)COCC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of 6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil

There total 8 articles about 6-Benzyl-1-benzyloxymethyl-5-isopropyl uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: 3587-60-8
Benzyloxymethyl chloride

: 176519-55-4
6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione

: 175739-42-1
6-benzyl-1-[(benzyloxy)methyl]-5-isopropylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane;

Benzyloxymethyl chloride; With lithium iodide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/jhet.987

Reference yield:

: 176519-53-2
ethyl 2-isopropyl-3-oxo-4-phenylbutanoate

: 175739-42-1
6-benzyl-1-[(benzyloxy)methyl]-5-isopropylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / isopropyl alcohol / Inert atmosphere

1.2: Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide; tetra-(n-butyl)ammonium iodide / dichloromethane / 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In dichloromethane; isopropyl alcohol;
DOI:10.1021/ml1002162

Reference yield:

: 609-12-1
ethyl 2-bromoisovalerate

: 175739-42-1
6-benzyl-1-[(benzyloxy)methyl]-5-isopropylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; zinc / tetrahydrofuran / Inert atmosphere

2.1: potassium tert-butylate / isopropyl alcohol / Inert atmosphere

2.2: Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide; tetra-(n-butyl)ammonium iodide / dichloromethane / 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; potassium tert-butylate; iodine; tetra-(n-butyl)ammonium iodide; zinc; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml1002162