trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

Base Information

Chemical Name:trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide
CAS No.:1351947-24-4
Molecular Formula:C₁₉H₃₀N₄O₂
Molecular Weight:346.473
Hs Code.:

Synonyms:trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

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Chemical Property of trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

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Technology Process of trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

There total 7 articles about trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1351947-13-1
tert-butyl (trans-4-{[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]carbamoyl}cyclohexyl)carbamate

: 1351947-24-4
trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 54-11-5
nicotin

: 1351947-24-4
trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / 1,4-dioxane / 16 h / 85 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h

4.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 21 h

5.1: trifluoroacetic acid / dichloromethane / 20 °C

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; bis(pinacol)diborane; 4,4'-di-tert-butyl-2,2'-bipyridine; In 2-methyltetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1351946-87-6
(S)-5-(1-methylpyrrolidin-2-yl)pyridin-3-ol

: 1351947-24-4
trans-4-amino-N-[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 21 h

4: trifluoroacetic acid / dichloromethane / 20 °C

With potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; trifluoroacetic acid; In 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;