5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

Base Information

Chemical Name:5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole
CAS No.:886548-34-1
Molecular Formula:C₂₇H₃₅BFNO₄
Molecular Weight:467.389
Hs Code.:

Synonyms:5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

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Chemical Property of 5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

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Technology Process of 5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

There total 2 articles about 5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148562-16-7
2-(5-bromopentyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 886548-34-1
5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

Guidance literature:: 5-fluoro-2-(3,4-dimethoxyphenyl)-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-(5-bromopentyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 120986-85-8
5-bromopentyl boronic acid

: 886548-34-1
5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 16 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 2 h

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 886548-34-1
5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole

: 5-(5-Fluoro-2-(3,4-dimethoxyphenyl)-1H-indol-1-yl)pentylboronic acid

Guidance literature:: 5-fluoro-2-(3,4-dimethoxyphenyl)-1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaboirolan-2-yl)pentyl)-1H-indole; With 2,2'-iminobis[ethanol]; In diethyl ether; at 40 ℃; for 20h;

With hydrogenchloride; In dichloromethane; water; for 0.333333h;