5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester

Base Information

• Chemical Name: 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester
• CAS No.: 66635-94-7
• Molecular Formula: C₁₉H₂₀FNO₃
• Molecular Weight: 329.371

Synonyms:5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester

Chemical Property of 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester

Chemical Property:

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Technology Process of 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester

There total 2 articles about 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-4-fluorobenzamide (24167-56-4) + i-propyl 6-methyl-1,2-dihydro-3H-pyrrolo<1,2-a>-1-carboxylate (68204-67-1) → 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester (66635-94-7)

Guidance literature:

With trichlorophosphate; Yield given. Multistep reaction; 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 15 h;

DOI:10.1021/jm00388a013

Reference yield:

→ 5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester (66635-94-7)

Guidance literature:

/BRN= 399185/ + /BRN= 387972/ + POCl3;

Reference yield: 75.0%

5-(4-Fluoro-benzoyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid isopropyl ester (66635-94-7) → 5-p-fluorobenzoyl-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (107115-74-2)

Guidance literature:

With potassium carbonate; In methanol; water; for 3h; Heating;

DOI:10.1021/jm00388a013

upstream raw materials:

N,N-dimethyl-4-fluorobenzamide

i-propyl 6-methyl-1,2-dihydro-3H-pyrrolo<1,2-a>-1-carboxylate

Downstream raw materials:

5-p-fluorobenzoyl-1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid

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