Chemical Property of Esterastin
Chemical Property:
- Vapor Pressure:3.35E-20mmHg at 25°C
- Boiling Point:713.4°C at 760 mmHg
- Flash Point:385.3°C
- PSA：124.79000
- Density:1.058g/cm3
- LogP:5.74450
- Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
- XLogP3:5.9
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:21
- Exact Mass:506.33558719
- Heavy Atom Count:36
- Complexity:748
- Purity/Quality:
-
95% *data from raw suppliers
ESTERASTIN 95.00% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CCCCCCC1C(OC1=O)CC(CC=CCC=CCCCCC)OC(=O)C(CC(=O)N)NC(=O)C
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Uses
Esterastin is a potent inhibitor of lysosomal acid lipase. Esterastin inhibited the enzyme activity very strongly (IC50, about 80 nM). The inhibition of acid lipase by Esterastin was competitive with respect to the substrate and the inhibition constant for Esterastin was 90 nM. Esterastin was less inhibitory to other lipolytic enzymes, such as pancreatic lipase and carboxylesterase. Thus, Esterastin is a potent new inhibitor of lysosomal acid lipase.
