N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

Base Information

Chemical Name:N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine
CAS No.:1345983-06-3
Molecular Formula:C₂₅H₃₄N₂O₆S
Molecular Weight:490.621
Hs Code.:

Synonyms:N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

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Chemical Property of N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

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Technology Process of N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

There total 7 articles about N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₂N₂O₆S

: 1345983-06-3
N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

Guidance literature:: C₂₉H₄₂N₂O₆S; With sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; at 22 ℃; for 2h;

With trifluoroacetic acid; In methanol; dichloromethane; at 22 ℃; for 16h;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7,8-dimethoxy-5-phenyl-1-4-benzothiazepine-1,1-dioxide

: 1345983-06-3
N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; aluminum (III) chloride / 1,2-dichloro-ethane / 2.5 h / 20 °C

1.2: Cooling with ice

2.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

3.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C

4.2: 1 h / Cooling with ice

5.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

5.2: 1 h / 20 °C

5.3: 1 h

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 22 °C

7.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h / 22 °C

7.2: 16 h / 22 °C

With pyridine; hydrogenchloride; aluminum (III) chloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: (3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-5-phenyl-1,4-benzothiazepine-8-ol 1,1-dioxide

: 1345983-06-3
N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-N-hydroxyglycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere

2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 8.25 h / 20 - 80 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / 0 °C

3.2: 1 h / Cooling with ice

4.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 1 h / 20 °C

4.3: 1 h

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 22 °C

6.1: sodium cyanoborohydride; acetic acid / dichloromethane; methanol / 2 h / 22 °C

6.2: 16 h / 22 °C

With pyridine; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;