2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

Base Information

Chemical Name:2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile
CAS No.:1581692-21-8
Molecular Formula:C₃₅H₃₆N₈O₃
Molecular Weight:616.723
Hs Code.:

2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

Synonyms:2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

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Chemical Property of 2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

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Technology Process of 2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

There total 5 articles about 2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1581692-41-2
2-(2-{2-formyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

: 1581692-21-8
2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

Guidance literature:: With methanol; sodium tetrahydroborate; In dichloromethane; water; at 0 ℃; for 0.333333h;

Reference yield:

: 67713-23-9
2,6-dibromobenzaldehyde

: 1581692-21-8
2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; copper(l) iodide / dimethyl sulfoxide / 2 h / 110 °C

2.1: potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / butan-1-ol; 1,4-dioxane; water / Inert atmosphere; Heating

2.2: 20 °C / Heating

3.1: sodium tetrahydroborate; methanol / dichloromethane; water / 0.33 h / 0 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium hydrogencarbonate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 1581692-36-5
2-methyl-2-(1-oxo-1,2-dihydrophthalazin-6-yl)propionitrile

: 1581692-21-8
2-(2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-1-oxo-1,2-dihydrophthalazin-6-yl)-2-methylpropionitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; copper(l) iodide / dimethyl sulfoxide / 2 h / 110 °C

2.1: potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine / butan-1-ol; 1,4-dioxane; water / Inert atmosphere; Heating

2.2: 20 °C / Heating

3.1: sodium tetrahydroborate; methanol / dichloromethane; water / 0.33 h / 0 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium hydrogencarbonate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;