N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

Base Information

• Chemical Name: N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
• CAS No.: 415711-30-7
• Molecular Formula: C₃₂H₃₅N₃O₇
• Molecular Weight: 573.646
• Mol file: 415711-30-7.mol

Synonyms:N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

Chemical Property of N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

There total 7 articles about N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

thymidyl acetic acid (20924-05-4) + (2R,3R)-3-amino-4-(bis(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol → N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (415711-30-7)

Guidance literature:

With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 76.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + C11H17N3O5 → N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (415711-30-7)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4.5h; Inert atmosphere; Cooling with ice;

DOI:10.3390/molecules191117872

Reference yield:

thymidyl acetic acid (20924-05-4) → N-((2R,3R)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxybutan-2-yl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (415711-30-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; pyridine / 0 - 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3: pyridine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4.5 h / 20 °C / Inert atmosphere; Cooling with ice

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.3390/molecules191117872

upstream raw materials:

thymidyl acetic acid

N-{1-{[(4,4'-dimethoxytrityl)oxy]methyl}-2-hydroxypropyl}-2,2,2-trifluoroacetamide

4,4'-dimethoxytrityl chloride

ethyl 2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate