1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

Base Information

Chemical Name:1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide
CAS No.:1141896-04-9
Molecular Formula:C₁₉H₂₂BrF₃N₆O₂
Molecular Weight:503.322
Hs Code.:

Synonyms:1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

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Chemical Property of 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

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Technology Process of 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

There total 6 articles about 1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1584224-47-4
N-(4-bromo-2-(trifluoromethoxy)benzyl)piperidine-4-carboxamide

: 57639-19-7
4?chloro?N,6?dimethyl?1,3,5?triazin?2?amine

: 1141896-04-9
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol500593v

Reference yield: 2.0%

: 1141894-78-1
1-{4-bromo-2-[(trifluoromethyl)oxy]phenyl}methanamine trifluoroacetate

: 1141894-74-7
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-4-piperidinecarboxylicacid

: 1141896-04-9
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 8 ℃; for 96h;

Reference yield: 2.0%

: 1141894-74-7
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-4-piperidinecarboxylicacid

: 1-{4-bromo-2-[(trifluoromethyl)oxy]phenyl}methanamine TFA salt

: 1141896-04-9
1-[4-methyl-6-(methylamino)-1,3,5-triazin-2-yl]-N-[(4-bromo-2-trifluoromethoxy-phenyl)methyl]-4-piperidinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 8 ℃; for 96h;
DOI:10.1016/j.bmcl.2013.04.019