Myxalamid A

Base Information

Chemical Name:Myxalamid A
CAS No.:86934-09-0
Molecular Formula:C₂₆H₄₁NO₃
Molecular Weight:415.616
Hs Code.:
DSSTox Substance ID:DTXSID001318066
Nikkaji Number:J1.060.288B
Wikidata:Q76386782
Metabolomics Workbench ID:94410

Synonyms:myxalamid A;myxalamide A

Suppliers and Price of Myxalamid A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Myxalamid A

Chemical Property:

Vapor Pressure:3.35E-18mmHg at 25°C
Boiling Point:624.3°C at 760 mmHg
Flash Point:331.4°C
PSA：69.56000
Density:0.986g/cm³
LogP:5.42490
XLogP3:6.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:12
Exact Mass:415.30864417
Heavy Atom Count:30
Complexity:695

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C=C(C)C(C(C)C=C(C)C=CC=CC=CC=C(C)C(=O)NC(C)CO)O
Isomeric SMILES:CC[C@H](C)/C=C(\C)/[C@@H]([C@H](C)/C=C(\C)/C=C/C=C\C=C\C=C(/C)\C(=O)N[C@@H](C)CO)O

Technology Process of Myxalamid A

There total 20 articles about Myxalamid A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220263-97-8
(E)-(2R,3S)-5-tert-Butylsulfanyl-2,4-dimethyl-pent-4-ene-1,3-diol

: 86934-09-0
Myxalamid A

Guidance literature:: Multi-step reaction with 18 steps

1: 88 percent / Et₃N imidazole

2: 92 percent / pyridine

3: 1.) LDA, 2.) TBSCl, HMPA, 4.) aq. K₂CO₃ / 1.) THF, -78 deg C, 3.) -78 deg C to room temperature, 4.) THF

5: LiAlH₄

6: Et₃N, DMAP

7: 94 percent / CuCN / 0 °C

8: m-CPBA

9: (MeO)3P / methanol

10: Et₃N

11: H₂SO₄ / tetrahydrofuran

12: 96 percent / TPAP, NMO

13: 56 percent

14: 95 percent / DIBALH

15: 100 percent / TPAP, NMO

16: KOt-Bu

17: TBAF / tetrahydrofuran

18: 1.) catecholborane, N,N-diethylaniline, 2.) TPPTS, i-Pr₂NH / 2.) Pd(OAc)2 / 2.) MeCN, H₂O

With pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; trisodium tris(3-sulfophenyl)phosphine; diisobutylaluminium hydride; potassium carbonate; tert-butyldimethylsilyl chloride; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; lithium diisopropyl amide; phosphorous acid trimethyl ester; benzo[1,3,2]dioxaborole; palladium diacetate; In tetrahydrofuran; methanol;
DOI:10.1021/jo9813742

Reference yield:

: 220264-05-1
(E)-(2R,3R,6S)-1-(tert-Butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-oct-4-en-3-ol

: 86934-09-0
Myxalamid A

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N

2: H₂SO₄ / tetrahydrofuran

3: 96 percent / TPAP, NMO

4: 56 percent

5: 95 percent / DIBALH

6: 100 percent / TPAP, NMO

7: KOt-Bu

8: TBAF / tetrahydrofuran

9: 1.) catecholborane, N,N-diethylaniline, 2.) TPPTS, i-Pr₂NH / 2.) Pd(OAc)2 / 2.) MeCN, H₂O

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; trisodium tris(3-sulfophenyl)phosphine; diisobutylaluminium hydride; triethylamine; diisopropylamine; N,N-diethylaniline; benzo[1,3,2]dioxaborole; palladium diacetate; In tetrahydrofuran;
DOI:10.1021/jo9813742

Reference yield:

: 220263-99-0
(E)-(3S,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-tert-butylsulfanyl-2,4-dimethyl-pent-1-en-3-ol

: 86934-09-0
Myxalamid A

Guidance literature:: Multi-step reaction with 17 steps

1: 92 percent / pyridine

2: 1.) LDA, 2.) TBSCl, HMPA, 4.) aq. K₂CO₃ / 1.) THF, -78 deg C, 3.) -78 deg C to room temperature, 4.) THF

4: LiAlH₄

5: Et₃N, DMAP

6: 94 percent / CuCN / 0 °C

7: m-CPBA

8: (MeO)3P / methanol

9: Et₃N

10: H₂SO₄ / tetrahydrofuran

11: 96 percent / TPAP, NMO

12: 56 percent

13: 95 percent / DIBALH

14: 100 percent / TPAP, NMO

15: KOt-Bu

16: TBAF / tetrahydrofuran

17: 1.) catecholborane, N,N-diethylaniline, 2.) TPPTS, i-Pr₂NH / 2.) Pd(OAc)2 / 2.) MeCN, H₂O

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; sulfuric acid; potassium tert-butylate; tetrabutyl ammonium fluoride; trisodium tris(3-sulfophenyl)phosphine; diisobutylaluminium hydride; potassium carbonate; tert-butyldimethylsilyl chloride; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N,N-diethylaniline; lithium diisopropyl amide; phosphorous acid trimethyl ester; benzo[1,3,2]dioxaborole; palladium diacetate; In tetrahydrofuran; methanol;
DOI:10.1021/jo9813742