(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Base Information

Chemical Name:(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one
CAS No.:488097-12-7
Molecular Formula:C₄₃H₄₂N₂O₇S
Molecular Weight:730.882
Hs Code.:

(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Synonyms:(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Suppliers and Price of (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

There total 10 articles about (3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 122-51-0
orthoformic acid triethyl ester

: 488097-11-6
(3S,4S)-1-benzenesulfonyl-7-methoxymethoxy-5-oxo-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-1,2,3,4,5,6-hexahydrobenzo[b]azocine-9-carbaldehyde

: 488097-12-7
(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; at 20 ℃; for 5h;
DOI:10.1021/jo0206521

Reference yield:

: 26158-00-9,5928-72-3
benzene-sulfonic acid monohydrate

: 488097-12-7
(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / thionyl chloride / benzene / 3 h / Heating

2.1: 76 percent / pyridine / 14 h / 65 °C

3.1: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C

4.1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.33 h

5.1: oxalyl chloride; DMSO / CH₂Cl₂ / 3 h / -78 °C

5.2: 94 percent / triethylamine / CH₂Cl₂ / 0.17 h / -78 °C

6.1: 93 percent / p-toluenesulfonic acid / tetrahydrofuran; ethanol / 5 h / 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; oxalyl dichloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; benzene; 5.1: Swern oxidation;
DOI:10.1021/jo0206521

Reference yield:

: methyl (3S)-3-[N-[3-[N-(benzyloxycarbonyl)amino]-2-hydroxy-4-methoxy-4-oxobutyl]amino]-5-methoxymethoxy-4-methylbenzoate

: 488097-12-7
(3S,4S)-1-benzenesulfonyl-9-diethoxymethyl-7-methoxymethoxy-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-2,3,4,6-tetrahydro-1H-benzo[1,2-b]azocin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / 10percent Pd/C / methanol / 20 °C

2.1: K₃PO₄; Pb(NO₃)2 / acetonitrile / 36 h / 20 °C

2.2: 16.26 g / hydrochloric acid / methanol; H₂O / 1 h / Heating

3.1: 76 percent / pyridine / 14 h / 65 °C

4.1: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C

5.1: 97 percent / LiAlH₄ / tetrahydrofuran / 0.33 h

6.1: oxalyl chloride; DMSO / CH₂Cl₂ / 3 h / -78 °C

6.2: 94 percent / triethylamine / CH₂Cl₂ / 0.17 h / -78 °C

7.1: 93 percent / p-toluenesulfonic acid / tetrahydrofuran; ethanol / 5 h / 20 °C

With pyridine; potassium phosphate; lithium aluminium tetrahydride; lead(II) nitrate; oxalyl dichloride; hydrogen; potassium hexamethylsilazane; toluene-4-sulfonic acid; dimethyl sulfoxide; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile; 6.1: Swern oxidation;
DOI:10.1021/jo0206521