Technology Process of 3a-phenyl-3,3a,4,5-tetrahydro-2H-indole
There total 9 articles about 3a-phenyl-3,3a,4,5-tetrahydro-2H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Reagent/catalyst;
Temperature;
Time;
Inert atmosphere;
DOI:10.1021/ol302608q
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1021/ol302608q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: chromium(VI) oxide; 3,5-dimethyl-1H-pyrazole / dichloromethane / -10 °C / Inert atmosphere
1.2: 1 h / 20 °C
2.1: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere
3.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: lithium triethylborohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: di-isopropyl azodicarboxylate; triphenylphosphine; diphenylphosphoranyl azide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 50 °C
7.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
With
2,6-dimethylpyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; lithium triethylborohydride; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
7.1: |Schmidt Reaction;
DOI:10.1021/ol302608q
