Technology Process of chloro(phenyl)(3-pyridyl)phosphine
There total 1 articles about chloro(phenyl)(3-pyridyl)phosphine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-Bromopyridine;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
Inert atmosphere;
Dichlorophenylphosphine;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol102444j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
2: dihydrogen peroxide / dichloromethane; water / 20 °C / Inert atmosphere
With
dihydrogen peroxide;
In
tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ol102444j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere
2: dihydrogen peroxide / dichloromethane; water / 20 °C / Inert atmosphere
3: copper(l) iodide; trans-1,2-cyclohexyldiamine; caesium carbonate / 1,4-dioxane / Reflux; Inert atmosphere
With
copper(l) iodide; trans-1,2-cyclohexyldiamine; dihydrogen peroxide; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;
DOI:10.1021/ol102444j
