methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

Base Information

Chemical Name:methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate
CAS No.:1416324-52-1
Molecular Formula:C₂₆H₃₁NO₆
Molecular Weight:453.535
Hs Code.:

Synonyms:methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

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Chemical Property of methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

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Technology Process of methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

There total 1 articles about methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1416324-51-0
methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

Guidance literature:: methyl 3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decane-7-carboxylate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.16667h; Inert atmosphere;

Benzyloxymethyl chloride; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-54-3
(7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1416324-52-1
methyl 3-{[4-(methyloxy)phenyl]methyl}-2-oxo-7-{[(phenylmethyl)oxy]methyl}-1-oxa-3-azaspiro[4.5]decane-7-carboxylate

: 1416324-55-4
7-(azidomethyl)-7-((benzyloxy)methyl)-3-(4-methoxybenzyl)-1-oxa-3-azaspiro[4.5]decan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48.17 h / -78 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

3: sodium azide / dimethyl sulfoxide / 96 h / 120 °C

With lithium aluminium tetrahydride; sodium azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;