N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

Base Information

Chemical Name:N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide
CAS No.:1428445-73-1
Molecular Formula:C₁₉H₁₅F₃IN₃O
Molecular Weight:485.247
Hs Code.:

Synonyms:N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

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Technology Process of N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

There total 3 articles about N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₁₁H₁₀F₃N₃

: 52107-98-9
3-iodo-4-methylbenzoyl chloride

: 1428445-73-1
N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jm400099d

Reference yield:

: C₁₁H₈F₃N₃O₂

: 1428445-73-1
N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: raney nickel (catcart) / methanol / 40 °C

2: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 °C

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm400099d

Reference yield:

: 694499-22-4
1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene

: 1428445-73-1
N-(4-((1H-imidazol-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1 h

2: raney nickel (catcart) / methanol / 40 °C

3: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 25 °C

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm400099d