ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate

Base Information

• Chemical Name: ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate
• CAS No.: 727678-55-9
• Molecular Formula: C₂₃H₂₂N₂O₆
• Molecular Weight: 422.437

Synonyms:ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate

Chemical Property of ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate

There total 2 articles about ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-acetylamino-2-cyano-3-(3,4-piperyl)-5-oxo-5-phenylpentanoate (727678-33-3) → ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate (727678-55-9)

Guidance literature:

With hydrogenchloride; In acetic acid; at 20 ℃;

DOI:10.1055/s-2004-822325

Reference yield:

ethyl 2-acetamido-2-cyanoacetate (90877-70-6,4977-62-2) → ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate (727678-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / t-BuONa / tetrahydrofuran / 0.5 h / 20 °C

2: 90 percent / aq. HCl / acetic acid / 20 °C

With hydrogenchloride; sodium t-butanolate; In tetrahydrofuran; acetic acid; 1: Michael addition;

DOI:10.1055/s-2004-822325

Reference yield: 82.0%

ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate (727678-55-9) → ethyl 1,2-dihydro-4-(3,4-piperyl)-6-phenyl-2-oxo-3-pyridinecarboxylate

Guidance literature:

With sodium carbonate; In dimethyl sulfoxide; at 140 ℃; for 1h;

DOI:10.1055/s-2004-822325

upstream raw materials:

ethyl 2-acetylamino-2-cyano-3-(3,4-piperyl)-5-oxo-5-phenylpentanoate

ethyl 2-acetamido-2-cyanoacetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 727678-55-9 ethyl 3-acetylamino-3,4-dihydro-4-(3,4-piperyl)-6-phenyl-2(1H)pyridone-3-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send