2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Name:2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1446712-37-3
Molecular Formula:C₂₂H₁₄ClF₃IN₅O
Molecular Weight:583.739
Hs Code.:

Synonyms:2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 4 articles about 2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228787-02-7
4-amino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

: 1446712-37-3
2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With diiodomethane; isopentyl nitrite; at 85 ℃;

Reference yield:

: 1446712-53-3
5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazole-1-carboximidamide

: 1446712-37-3
2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

2: isopentyl nitrite; diiodomethane / 85 °C

With diiodomethane; potassium tert-butylate; isopentyl nitrite; In tert-butyl alcohol;

Reference yield:

: 2-[1-(2-bromo-5-chlorophenyl)-2-(2,3,6-trifluorophenyl)ethylidene]hydrazinecarboximidamide

: 1446712-37-3
2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; ammonium hydroxide / 1-methyl-pyrrolidin-2-one / 0.25 h / 170 °C / Cooling with ice

2: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

3: isopentyl nitrite; diiodomethane / 85 °C

With ammonium hydroxide; copper(l) iodide; diiodomethane; potassium tert-butylate; isopentyl nitrite; In 1-methyl-pyrrolidin-2-one; tert-butyl alcohol;