4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile

Base Information

• Chemical Name: 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile
• CAS No.: 1281819-15-5
• Molecular Formula: C₁₈H₁₁ClF₂N₄
• Molecular Weight: 356.762
• Mol file: 1281819-15-5.mol

Synonyms:4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile

Chemical Property of 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile

There total 3 articles about 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-(4-(2,6-difluorobenzyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino)benzonitrile (1281819-06-4) → 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile (1281819-15-5)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 0 - 20 ℃;

DOI:10.1021/jm101626c

Reference yield:

N-(4-cyanophenyl)guanidine nitrate → 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile (1281819-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / Reflux

2: N,N-dimethyl-formamide; trichlorophosphate / 0 - 20 °C

With sodium ethanolate; N,N-dimethyl-formamide; trichlorophosphate; In ethanol; 2: Vilsmeier reaction;

DOI:10.1021/jm101626c

Reference yield:

ethyl 4-(2,6-difluorophenyl)-3-oxobutanoate (221121-46-6) → 4-(4-chloro-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile (1281819-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethanol / Reflux

2: N,N-dimethyl-formamide; trichlorophosphate / 0 - 20 °C

With sodium ethanolate; N,N-dimethyl-formamide; trichlorophosphate; In ethanol; 2: Vilsmeier reaction;

DOI:10.1021/jm101626c

upstream raw materials:

4-(4-(2,6-difluorobenzyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino)benzonitrile

ethyl 4-(2,6-difluorophenyl)-3-oxobutanoate

Downstream raw materials:

4-(4-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile

4-(4-amino-6-(2,6-difluorobenzyl)pyrimidin-2-ylamino)benzonitrile