(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

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Chemical Name:(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid
CAS No.:1268705-22-1
Molecular Formula:C₂₄H₂₃F₃N₂O₄S
Molecular Weight:492.519
Hs Code.:

Synonyms:(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

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Chemical Property of (E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

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Technology Process of (E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

There total 4 articles about (E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1268705-15-2
(E)-ethyl 2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetate

: 1268705-22-1
(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2010.12.023

Reference yield:

: 1268705-04-9
(E)-ethyl 2-(4-(1-(hydroxyimino)propyl)-2-methylphenoxy)acetate

: 1268705-22-1
(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 18 h / 20 °C

With lithium hydroxide monohydrate; caesium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.023

Reference yield:

: 940-04-5
1-(4-hydroxy-3-methylphenyl)propan-1-one

: 1268705-22-1
(E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)imino)propyl)phenoxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

2: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 18 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; sodium acetate; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.023