Chemical Property of Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-1,5,11,14,19-pentahydroxy-, octahydrate, (1beta,3beta,5beta,11alpha)-
Chemical Property:
- Melting Point:260 °C
- Boiling Point:838.2 °C at 760 mmHg
- Flash Point:272.9 °C
- PSA：280.44000
- Density:1.51 g/cm3
- LogP:-2.02940
- Storage Temp.:+2C to +8C
- Sensitive.:Light Sensitive
- Solubility.:H2O: 10 mg/mL cold
- Water Solubility.:Soluble in water.
- Hydrogen Bond Donor Count:16
- Hydrogen Bond Acceptor Count:20
- Rotatable Bond Count:4
- Exact Mass:728.36779430
- Heavy Atom Count:49
- Complexity:1080
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Ouabain octahydrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T
- Statements:
23/25-33
- Safety Statements:
45
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O.O.O.O.O.O.O.O.O
- Isomeric SMILES:CC1C(C(C(C(O1)O[C@H]2C[C@H](C3([C@H]4[C@@H](CC5([C@H](CCC5(C4CCC3(C2)O)O)C6=CC(=O)OC6)C)O)CO)O)O)O)O.O.O.O.O.O.O.O.O
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Description
Ouabain (11018-89-6) is a selective inhibitor of Na+ K+-ATPase isolated from Strophanthus gratus.1 Endogenous ouabain is found in human circulation.2 Displays cardiotonic and diuretic activity. May be used to induce hypertensive rat model.3?Cell permeable and active in vivo.
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Uses
A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1. antiarrhythmic, cardiotonic, hypertensive, Na/K ATPase inhibitor 5HT2 receptor antagonist Ouabain octahydrate, is used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.
