2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol

Base Information

Chemical Name:2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol
CAS No.:1314242-01-7
Molecular Formula:C₂₁H₁₉NOS
Molecular Weight:333.454
Hs Code.:
DSSTox Substance ID:DTXSID901159455
Nikkaji Number:J3.371.848I
ChEMBL ID:CHEMBL1915484

Synonyms:CHEMBL1915484;DTXSID901159455;BDBM50357697;2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol;2-[1,1'-Biphenyl]-4-yl-3,4-dihydro-4-methyl-2H-1,4-benzothiazin-2-ol;1314242-01-7

Suppliers and Price of 2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:333.11873540
Heavy Atom Count:24
Complexity:416

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1CC(SC2=CC=CC=C21)(C3=CC=C(C=C3)C4=CC=CC=C4)O

Technology Process of 2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol

There total 9 articles about 2-(4-Biphenylyl)-4-methyl-3,4-dihydro-2H-1,4-benzothiazine-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4-formyl-2-(4-biphenylyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol

: 1314242-01-7
4-methyl-2-(4-biphenylyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.12.046

Reference yield: 48.0%

: 1314242-06-2
2-(4-biphenyl)-2-hydroxy-4-methyl-4H-benzo[1,4]thiazin-3-one

: 1314242-01-7
4-methyl-2-(4-biphenylyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm200763k

Reference yield:

: 5728-52-9
(4-biphenylyl)acetic acid

: 1314242-01-7
4-methyl-2-(4-biphenylyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / water / Reflux

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

3.1: N,N-dimethyl-formamide / 25 h / 20 °C

4.1: potassium hydroxide / acetone / 0.25 h / 60 °C

5.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 3 h / 20 °C

5.2: silica gel

6.1: borane-THF / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; borane-THF; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; 5.2: Pummerer reaction;
DOI:10.1021/jm200763k