[2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester

Base Information

• Chemical Name: [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester
• CAS No.: 660870-76-8
• Molecular Formula: C₁₆H₂₆I₂O₆P₂
• Molecular Weight: 630.135
• Mol file: 660870-76-8.mol

Synonyms:[2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester

Chemical Property of [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester

There total 3 articles about [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,5-diiodo-1,4-bis(bromomethyl)benzene (56403-29-3) + triethyl phosphite (122-52-1) → [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester (660870-76-8)

Guidance literature:

at 150 ℃;

DOI:10.2533/chimia.2010.140

Reference yield:

2,5-diiodo-p-xylene (1124-08-9) → [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester (660870-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / ethylene dibromide / 135 °C

2: 150 °C

With bromine; In ethylene dibromide; 2: Arbuzov reaction;

DOI:10.2533/chimia.2010.140

Reference yield:

para-xylene (106-42-3) → [2,5-dichloro-4-(diethoxyphosphorylmethyl)benzyl]phosphonic acid diethyl ester (660870-76-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; iodic acid; acetic acid / 85 °C

2: bromine / ethylene dibromide / 135 °C

3: 150 °C

With sulfuric acid; bromine; iodic acid; acetic acid; In ethylene dibromide; 3: Arbuzov reaction;

DOI:10.2533/chimia.2010.140

upstream raw materials:

2,5-diiodo-1,4-bis(bromomethyl)benzene

triethyl phosphite

2,5-diiodo-p-xylene

para-xylene

Downstream raw materials:

C₂₀H₁₄I₂N₂

1,4-Diiodo-2,5-bis-[(E)-2-(4-trifluoromethyl-phenyl)-vinyl]-benzene

1,4-bis(styryl)-2,5-diiodobenzene

1,4-Diiodo-2,5-bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzene