Norfenefrine

Base Information

Chemical Name:Norfenefrine
CAS No.:536-21-0
Deprecated CAS:13026-50-1
Molecular Formula:C8H11 N O2
Molecular Weight:153.181
Hs Code.:
European Community (EC) Number:208-626-8,239-351-1
UNII:D2P3M6SRN5
DSSTox Substance ID:DTXSID3048314
Nikkaji Number:J6.350I
Wikipedia:Norfenefrine
Wikidata:Q12746348
NCI Thesaurus Code:C84022
Metabolomics Workbench ID:154191
ChEMBL ID:CHEMBL358040
Mol file:536-21-0.mol

Synonyms:3-octopamine;A.S. COR;alpha-(aminomethyl)-3-hydroxybenzyl alcohol;m-octopamine;Norfenefrin Ziethen;Norfenefrin-ratiopharm;norfenefrine;norfenefrine citrate (1:1), (R)-(R-(R*,R*))-isomer;norfenefrine citrate (1:1), (R-(R*,R*))-isomer;norfenefrine hydrochloride;norfenefrine hydrochloride, (+,-)-isomer;norfenefrine hydrochloride, (R)-isomer;norfenefrine hydrochloride, (S)-isomer;norfenefrine sulfate;norfenefrine, (+)-isomer;norfenefrine, (+,-)-isomer;norfenefrine, (-)-isomer;norfenefrine, 2H-labeled cpd;norphenylephrine;Novadral

Suppliers and Price of Norfenefrine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(2-AMINO-1-HYDROXYETHYL)PHENOL 95.00%
0.5G
$ 605.00

Total 8 raw suppliers

Chemical Property of Norfenefrine

Chemical Property:

Vapor Pressure:7.82E-06mmHg at 25°C
Melting Point:75-77 °C
Refractive Index:1.5010 (estimate)
Boiling Point:360.7°Cat760mmHg
PKA:pKa 8.67(H2O,t undefined,I undefined) (Uncertain)
Flash Point:172°C
PSA：66.48000
Density:1.249g/cm³
LogP:1.08460
XLogP3:-0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:153.078978594
Heavy Atom Count:11
Complexity:119

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-AMINO-1-HYDROXYETHYL)PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)O)C(CN)O

Technology Process of Norfenefrine

There total 15 articles about Norfenefrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 620-18-8,24979-69-9
3-hydroxystyrene

: 536-21-0
norfenefrine

Guidance literature:: With iron(II) phthalocyanine; O-pivaloylhydroxylamine trifluoromethanesulfonate salt; In water; acetonitrile; at 20 ℃; for 16h;
DOI:10.1039/c8gc03823f

Reference yield:

: 852159-27-4
1-(3-hydroxyphenyl)-2-nitro-ethanol

: 536-21-0
norfenefrine

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / CH₂Cl₂

2: H₂ / Raney nickel / methanol

3: Bu₄NF / tetrahydrofuran

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; nickel; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.11.041

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 536-21-0
norfenefrine

Guidance literature:: Multi-step reaction with 4 steps

1: aq. AcOH; NaOH / ethanol

2: imidazole / CH₂Cl₂

3: H₂ / Raney nickel / methanol

4: Bu₄NF / tetrahydrofuran

With 1H-imidazole; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.11.041