1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

Base Information

Chemical Name:1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene
CAS No.:891202-18-9
Molecular Formula:C₂₅H₃₁BrO₂
Molecular Weight:443.424
Hs Code.:

Synonyms:1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

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Chemical Property of 1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

Chemical Property:

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Technology Process of 1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

There total 6 articles about 1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 891202-10-1
2-(4-benzyloxy-2-bromo-5-methoxybenzyl)-3,3-dimethylcyclohexanone

: 4736-60-1
ethyltriphenylphosphonium iodide

: 891202-18-9
1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

Guidance literature:: ethyltriphenylphosphonium iodide; With potassium tert-butylate; In toluene; at 20 ℃; for 2h;

2-(4-benzyloxy-2-bromo-5-methoxybenzyl)-3,3-dimethylcyclohexanone; In toluene; at 20 ℃; for 12h;
DOI:10.1055/s-2006-926408

Reference yield:

: 891202-08-7
2-(4-benzyloxy-2-bromo-5-methoxybenzyl)-3-methylcyclohex-2-enone

: 891202-18-9
1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / diethyl ether / 0.5 h / -25 °C

1.2: 81 percent / BF₃*Et₂O / diethyl ether / -30 - 0 °C

2.1: t-BuOK / toluene / 2 h / 20 °C

2.2: 94 percent / toluene / 12 h / 20 °C

With copper(l) iodide; potassium tert-butylate; In diethyl ether; toluene; 2.2: Wittig olefination;
DOI:10.1055/s-2006-926408

Reference yield:

: 891202-07-6
3-(4-benzyloxy-2-bromo-5-methoxybenzyl)-2-methyl-4-oxocyclohex-2-enecarboxylic acid methyl ester

: 891202-18-9
1-benzyloxy-5-bromo-4-(6-ethylidene-2,2-dimethylcyclohexylmethyl)-2-methoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiOH*H₂O / aq. methanol / 16 h / 20 °C

2.1: 13.8 g / silica gel / CH₂Cl₂ / 4 h / 90 °C

3.1: CuI / diethyl ether / 0.5 h / -25 °C

3.2: 81 percent / BF₃*Et₂O / diethyl ether / -30 - 0 °C

4.1: t-BuOK / toluene / 2 h / 20 °C

4.2: 94 percent / toluene / 12 h / 20 °C

With lithium hydroxide; copper(l) iodide; potassium tert-butylate; silica gel; In methanol; diethyl ether; dichloromethane; toluene; 4.2: Wittig olefination;
DOI:10.1055/s-2006-926408